Sepsis-induced tissue hypoperfusion.

The understanding of sepsis is continuously evolving. An overview of sepsis-induced tissue hypoperfusion has been provided herein. It is of critical importance that the clinician understands the pathophysiology of this emergent condition and is able to synthesize the available data in a rapid fashion so that tissue hypoperfusion is readily detected. Once detected, aggressive and endpoint-directed resuscitation should be implemented to reverse the hypoperfusion and to prevent further deterioration, organ dysfunction, and death.